A little and little refer to non-count nouns, and is used with the singular form:
A few and few refer to count nouns, and are used with the plural form:
Examples:
There's little wine left in the bottle.
I've put a little sugar into your coffee.
There are a few students in that classroom.
He says few applicants have presented themselves.
A little and a few convey a positive meaning.
Examples:
I've got a little wine left, would you like some?
They've got a few positions open.
Little and few convey a negative meaning.
Examples:
He's got little money left.
I have few friends in Chicago.
source from http://esl.about.com/od/grammarintermediate/a/cm_littlefew.htm
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